ENDOGLIN INHIBITION LEADS TO INTUSSUSCEPTIVE ANGIOGENESIS VIA ACTIVATION OF FACTORS RELATED TO COUP-TFII SIGNALING PATHWAY.

Endoglin inhibition leads to intussusceptive angiogenesis via activation of factors related to COUP-TFII signaling pathway.

Angiogenesis is a highly coordinated, extremely complex process orchestrated by multiple signaling molecules and blood flow conditions.While sprouting Antiseptic mode of angiogenesis is very well investigated, the molecular mechanisms underlying intussusception, the second mode of angiogenesis, remain largely unclear.In the current study two molecu

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Metabolic engineering to simultaneously activate anthocyanin and proanthocyanidin biosynthetic pathways in Nicotiana spp.

Proanthocyanidins (PAs), or condensed tannins, are powerful antioxidants that remove harmful free oxygen radicals from cells.To engineer the anthocyanin and proanthocyanidin biosynthetic pathways to de novo produce PAs in two Nicotiana species, we incorporated four transgenes to the plant chassis.We opted to perform a simultaneous transformation of

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Analysis on the selection of brake shoe and wheel for an engineering train from the perspective of braking safety

For an engineering train with maximum running speed up to 160 km/h and axle load of 21 t, the brake shoe type, single and double side braking type and wheel diameter were confirmed by analysis in four aspects of braking distance limit, wheel-rail adhesion limit, wheel temperature limit and wheel strength requirement, BB Cream and the strength of th

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The Caucasus is neither a cradle nor a museum of diversity of the land snail genus Helix (Gastropoda, Stylommatophora, Helicidae), while Crimea is home to an ancient lineage

The Caucasus and the adjacent Pontic Mountains in north-eastern Anatolia are home to numerous endemic land snail genera and species.The diversity of the region is the result of both intra-regional speciation and the persistence of relict lineages.The same seemed to be true for the genus Helix, which has been present in the Greater Caucasus since th

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